Recent research brings medical investigators a step closer to unraveling one of the most intractable problems in medicine today, the mechanisms through which DNA damage and uncontrolled cell division leads to the break-down in homeostasis known as cancer. Published online in Molecular Carcinogenesis, a 2014 study by Colgate University and Memorial-Sloan Kettering researchers examined a pathway involving Krüppel-Like Factor 4 (KLF4), a protein in eukaryotic cells that regulates tumorigenesis. Previous research by El-Karim et al. had demonstrated that KLF4-deficient mouse cells are genetically unstable, putting them at increased risk for mutation leading to cancer. So the researcher’s experimental objective was to determine how the KLF4 pathway works to arrest cell growth in pre-cancerous mouse cells.
Showing posts with label p53. Show all posts
Showing posts with label p53. Show all posts
Friday, March 13, 2015
Understanding Mechanisms of Cancer: Krüppel-Like Factor 4
Recent research brings medical investigators a step closer to unraveling one of the most intractable problems in medicine today, the mechanisms through which DNA damage and uncontrolled cell division leads to the break-down in homeostasis known as cancer. Published online in Molecular Carcinogenesis, a 2014 study by Colgate University and Memorial-Sloan Kettering researchers examined a pathway involving Krüppel-Like Factor 4 (KLF4), a protein in eukaryotic cells that regulates tumorigenesis. Previous research by El-Karim et al. had demonstrated that KLF4-deficient mouse cells are genetically unstable, putting them at increased risk for mutation leading to cancer. So the researcher’s experimental objective was to determine how the KLF4 pathway works to arrest cell growth in pre-cancerous mouse cells.
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